Manuscript Details

Whitehouse, A. J., Varcin, K. J., Alvares, G. A., Barbaro, J., Bent, C., Boutrus, M., ... & Hudry, K. (2019). Pre-emptive intervention versus treatment as usual for infants showing early behavioural risk signs of autism spectrum disorder: a single-blind, randomised controlled trial. The Lancet Child & Adolescent Health, 3(9), 605-615.

Low rating
This manuscript received a low rating because it is a randomized-controlled trial with high-attrition that does not satisfy the baseline equivalence requirement.

Study reviewed under: Handbook of Procedures and Standards, Version 2.1
Study design characteristics contributing to rating
Design Random assignment compromised? Attrition Baseline equivalence Confounding factors? Valid, reliable measures?
Randomized controlled trial No High

Not established on race/ethnicity, socioeconomic status, or baseline measures of the outcome(s) in the analyzed sample

No

Measure validity and reliability is not assessed for findings that receive a low evidence rating; all findings in this manuscript rate low