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The Mother and Infant Home Visiting Program Evaluation-Strong Start (MIHOPE-Strong Start) is a national evaluation of the Maternal, Infant, and Early Childhood Home Visiting (MIECHV) Program for families enrolled in Medicaid or the Children’s Health Insurance Program. MIHOPE-Strong Start study participants were recruited from local programs that primarily served Medicaid beneficiaries from 2012 to 2015. Participants were eligible for the MIHOPE-Strong Start evaluation if they were no more than 32 weeks pregnant, were age 15 or older, spoke English or Spanish proficiently, and met the relevant eligibility criteria for the local home visiting model. A total of 1,872 participants were recruited for the study through Nurse Family Partnership (NFP) programs and randomly assigned to either the NFP home visiting intervention group (1,003 participants) or the comparison condition (869 participants). Up to 1,404 participants recruited for the study through NFP programs were included in the analyses: 760 in NFP and 644 in the comparison group. Similarly, up to 1,854 children were included in the study: 994 in NFP and 860 in the comparison group. Outcomes were measured at childbirth and when children were 12 months old. For MIHOPE-Strong Start participants recruited through NFP programs, 29 percent of participants were of Mexican origin, 19 percent were another Hispanic ethnicity, 16 percent were White, 26 percent were Black, and 10 percent were another race. Thirty-three percent did not have a high school diploma at study entry. At enrollment, the average age of participants recruited through NFP programs was 21.