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The Mother and Infant Home Visiting Program Evaluation-Strong Start (MIHOPE-Strong Start) is a national evaluation of the Maternal, Infant, and Early Childhood Home Visiting (MIECHV) Program for families enrolled in Medicaid or the Children’s Health Insurance Program. MIHOPE-Strong Start study participants were recruited from local programs that primarily served Medicaid beneficiaries from 2012 to 2015. Participants were eligible for the MIHOPE-Strong Start evaluation if they were no more than 32 weeks pregnant, were age 15 or older, spoke English or Spanish proficiently, and met the relevant eligibility criteria for the local home visiting model. A total of 1,028 participants were recruited for the study through Healthy Families America (HFA) programs and randomly assigned to either the HFA home visiting intervention group (569 participants) or the comparison condition (459 participants). Up to 848 participants recruited for the study through HFA programs were included in the analyses: 466 in HFA and 382 in the comparison group. Similarly, up to 1,036 children of these participants were included in the analyses: 575 in HFA and 461 in the comparison group. Outcomes were measured at childbirth and when children were 12 months old. For MIHOPE-Strong Start participants recruited through HFA programs, 18 percent of women were of Mexican origin, 15 percent were another Hispanic ethnicity, 30 percent were White, 28 percent were Black, and 9 percent were another race. Thirty-six percent had less than a high school diploma at study entry. At enrollment, the average age of participants recruited through HFA programs was 24.