Klinnert, M. D., Liu, A. H., Pearson, M. R., Ellison, M. C., Budhiraja, N., & Robinson, J. L. (2005). Short-term impact of a randomized multifaceted intervention for wheezing infants in low-income families. Archives of Pediatrics & Adolescent Medicine, 159(1), 75-82.
Model(s) Reviewed:
Childhood Asthma Prevention Study (CAPS)
| Screening decision | Screening conclusion | HomVEE procedures and standards version |
|---|---|---|
| Passes screens | Eligible for review | Version 1 |
| Rating | Design | Attrition | Baseline equivalence | Compromised randomization | Confounding factors | Valid, reliable measure(s) |
|---|---|---|---|---|---|---|
| High | Randomized controlled trial | Low | Not applicable | None | None | Not assessed in manuscripts reviewed before 2021 |
Notes:
High rating applies to most outcomes. Medical record outcomes receive a low rating because of high attrition and failure to demonstrate baseline equivalence.
| Study participants | Participants (infants and their families) were recruited from local hospitals and clinics in the Denver, Colorado, area and assigned randomly to either the intervention or the comparison group. Initially 181 infants were randomly assigned, 90 to the treatment group and 91 to the comparison group. At baseline, the study groups were split among European Americans (22 percent treatment, 21 percent control), African American (23 percent treatment, 22 percent control), U.S.-born Hispanic (33 percent treatment, 31 percent control) and foreign-born Hispanic (22 percent treatment, 20 percent control). Approximately half of each group had incomes less than $12,000 per year. Participants were followed for one year after baseline data were collected. |
|---|---|
| Setting | The study was conducted in Denver, Colorado. |
| Intervention services | The intervention included home visits conducted by specially trained nurses. The intervention began when infants were from 9 to 24 months old and continued for 12 months. Participants received approximately 15 visits (or telephone calls) by a public health nurse. Each visit lasted an average of 53 minutes. |
| Comparison conditions | Comparison group members received an educational video at the baseline interview that described risk factors for developing asthma and actions that caregivers can take to mediate the risks. |
| Subgroups examined |
This field lists subgroups examined in the manuscript (even if they were not replicated in other samples and not reported on the summary page for this model’s report). Subgroups are not listed for manuscripts reviewed before 2021. |
| Funding sources | National Institute of Allergy and Infectious Diseases; National Institute of Health/National Center for Research Resources. |
| Author affiliation | Mary D. Klinnert, a study author, is a developer of this model. |
| Peer reviewed | Peer reviewed status is not listed for manuscripts reviewed before 2021. |
Findings that rate moderate or high
| Rating | Outcome measure | Effect | Sample | Timing of follow-up | Sample size | Intervention group | Comparison group | Group difference | Effect size | Statistical significance | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| High | Cotinine level | FavorableUnfavorable or ambiguousNo Effect |
Denver, Colorado sample | 12 months | 130 children | = 0.66 | = 0.56 | Mean difference = 0.10 | HomVEE calculated = 0.25 | Not statistically significant, p = 0.28 | Cotinine level outcome based on logistic regression model. Outcome from logrnormal regression model had high attrition and is not included in this report.
|
| High | Functional Severity Score | FavorableUnfavorable or ambiguousNo Effect |
Denver, Colorado sample | 12 months | 150 children | Mean = 1.03 | Mean = 1.04 | Mean difference = -0.01 | Not available | Not Statistically significant, p = 0.60 |
| Rating | Outcome measure | Effect | Sample | Timing of follow-up | Sample size | Intervention group | Comparison group | Group difference | Effect size | Statistical significance | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| High | Caregiver quality of life score | FavorableUnfavorable or ambiguousNo Effect |
Denver, Colorado sample | 12 months | 143 parents | Mean = 6.47 | Mean = 6.34 | Mean difference = 0.13 | Not available | Not statistically significant, p = 0.72 |
| Rating | Outcome measure | Effect | Sample | Timing of follow-up | Sample size | Intervention group | Comparison group | Group difference | Effect size | Statistical significance | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| High | HOME score | FavorableUnfavorable or ambiguousNo Effect |
Denver, Colorado sample | 12 months | 137 parents | Mean = 36.66 | Mean = 36.64 | Mean difference = 0.02 | Not available | Not statistically significant, p = 0.94 | |
| High | Asthma knowledge score | FavorableUnfavorable or ambiguousNo Effect |
Denver, Colorado sample | 12 months | 150 parents | Mean = 5.20 | Mean = 4.84 | Mean difference = 0.36 | Not available | Statistically significant, p = 0.04 | |
| High | Cat dander | FavorableUnfavorable or ambiguousNo Effect |
Denver, Colorado sample | 12 months | 140 parents | = 0.33 | = 0.26 | Mean difference = 0.07 | HomVEE calculated = 0.20 | Not statistically significant, p = 0.25 | |
| High | Cockroach allergen | FavorableUnfavorable or ambiguousNo Effect |
Denver, Colorado sample | 12 months | 140 parents | = 0.01 | = 0.13 | Mean difference = -0.12 | HomVEE calculated = -1.62 | Statistically significant, p = 0.03 | |
| High | Collaborative relationship score | FavorableUnfavorable or ambiguousNo Effect |
Denver, Colorado sample | 12 months | 146 parents | Mean = 6.13 | Mean = 5.81 | Mean difference = 0.33 | Not available | Statistically significant, p = 0.04 | |
| High | Dog dander | FavorableUnfavorable or ambiguousNo Effect |
Denver, Colorado sample | 12 months | 141 parents | = 0.13 | = 0.24 | Mean difference = -0.11 | HomVEE calculated = -0.45 | Not statistically significant, p = -.07 |