Izzo, C., Eckenrode, J., Smith, E., Henderson, C., Cole, R., Kitzman, H., & Olds, D. L. (2005). Reducing the impact of uncontrollable stressful life events through a program of nurse home visitation for new parents. Prevention Science, 6(4), 269–274.
| Screening decision | Screening conclusion | HomVEE procedures and standards version |
|---|---|---|
| Passes screens | Eligible for review | Version 1 |
| Rating | Design | Attrition | Baseline equivalence | Compromised randomization | Confounding factors | Valid, reliable measure(s) |
|---|---|---|---|---|---|---|
| High | Randomized controlled trial | Low | Established on race/ethnicity and SES; outcomes not feasible to assess at baseline | None | None | Not assessed in manuscripts reviewed before 2021 |
In addition to the outcomes that received a high rating, substance use outcomes in the maternal health domain received a moderate rating because equivalence was not established on baseline measures of the outcomes.
| Study participants | Participants were 324 mothers and 315 of their first-born children. The mothers and children all participated in an RCT examining the Nurse-Family Partnership model in Elmira, NY in 1978. At the time of recruitment, participants were pregnant, first-time mothers who were less than 25 weeks pregnant. All participants were all either under the age of 19; unmarried; or had low socioeconomic status, as indicated by their Medicaid eligibility. |
|---|---|
| Setting | Elmira, NY, USA |
| Intervention services | The treatment group received in-home nurse visits from pregnancy through 24 months after birth, in addition to the same services as the comparison group. |
| Comparison conditions | Mothers in the comparison group received developmental and sensory screening for their children, clinical referrals, and transportation to prenatal and postnatal care. |
| Subgroups examined |
This field lists subgroups examined in the manuscript (even if they were not replicated in other samples and not reported on the summary page for this model’s report). Subgroups are not listed for manuscripts reviewed before 2021. |
| Funding sources | This study was supported with grants from the Prevention Research Branch of the National Institutes of Mental Health (R01-MH49381); the Assistant Secretary for Planning and Evaluation, U.S. Department of Health and Human Services (96ASPE278A); the Children's Bureau, U.S. Department of Health and Human Services (90-CA-1631). The research was also supported by an NIH Senior Research Scientist Award. |
| Author affiliation | David L. Olds, one of the study authors, is also the model developer. |
| Peer reviewed | Peer reviewed status is not listed for manuscripts reviewed before 2021. |
Clinicaltrials.gov Identifier: None found. Study registration was assessed by HomVEE beginning with the 2014 review.
Findings that rate moderate or high
| Rating | Outcome measure | Effect | Sample | Timing of follow-up | Sample size | Intervention group | Comparison group | Group difference | Effect size | Statistical significance | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| High | Mental health - Anxiety: Mental Health Inventory (MHI) |
FavorableUnfavorable or ambiguousNo Effect |
Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample |
15 years |
300 mothers | Unadjusted mean = 2.56 | Unadjusted mean = 2.56 | MD = 0.00 | HomVEE calculated = 0.00 | Not statistically significant, p = 1.00 |
Statistical significance is based on HomVEE calculations. |
| High | Mental health - Depression: Mental Health Inventory (MHI) |
FavorableUnfavorable or ambiguousNo Effect |
Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample |
15 years |
300 mothers | Unadjusted mean = 2.01 | Unadjusted mean = 2.02 | MD = -0.01 | HomVEE calculated = -0.01 | Not statistically significant, p = 0.95 |
Statistical significance is based on HomVEE calculations. |
| High | Mental health - Emotional stability: Mental Health Inventory (MHI) |
FavorableUnfavorable or ambiguousNo Effect |
Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample |
15 years |
300 mothers | Unadjusted mean = 3.75 | Unadjusted mean = 3.74 | MD = 0.01 | HomVEE calculated = 0.02 | Not statistically significant, p = 0.90 |
Statistical significance is based on HomVEE calculations. |
| High | Mental health - Positive well-being: Mental Health Inventory (MHI) |
FavorableUnfavorable or ambiguousNo Effect |
Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample |
15 years |
300 mothers | Unadjusted mean = 3.78 | Unadjusted mean = 3.79 | MD = -0.01 | HomVEE calculated = -0.02 | Not statistically significant, p = 0.90 |
Statistical significance is based on HomVEE calculations. |
| Moderate | Alcohol impairment score | FavorableUnfavorable or ambiguousNo Effect |
Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample | 15 years | 300 mothers | Unadjusted mean = 0.35 | Unadjusted mean = 0.37 | MD = -0.02 | HomVEE calculated = -0.02 | Not statistically significant, p = 0.87 | Statistical significance is based on HomVEE calculations. |
| Moderate | Substance use - # cigarettes smoked per day | FavorableUnfavorable or ambiguousNo Effect |
Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample | 15 years | 300 mothers | Unadjusted mean = 8.32 | Unadjusted mean = 10.56 | MD = -2.24 | HomVEE calculated = -0.21 | Not statistically significant, p = 0.11 | Statistical significance is based on HomVEE calculations. |
| Moderate | Substance use - binge drinking: # days had 5+ drinks in the past year | FavorableUnfavorable or ambiguousNo Effect |
Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample | 15 years | 300 mothers | Unadjusted mean = 11.70 | Unadjusted mean = 9.27 | MD = 2.43 | HomVEE calculated = 0.06 | Not statistically significant, p = 0.65 | Statistical significance is based on HomVEE calculations. |
| Rating | Outcome measure | Effect | Sample | Timing of follow-up | Sample size | Intervention group | Comparison group | Group difference | Effect size | Statistical significance | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| High | Parenting practices - Hostility: Child Report of Parental Behavior Inventory (CRPBI) |
FavorableUnfavorable or ambiguousNo Effect |
Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample |
15 years |
300 children | Unadjusted mean = 1.38 | Unadjusted mean = 1.99 | MD = -0.61 | HomVEE calculated = -1.22 | Statistically significant, p = 0.00 |
Statistical significance is based on HomVEE calculations. Negative effect is favorable to the intervention. |
| High | Parenting practices - Inconsistent discipline: Child Report of Parental Behavior Inventory (CRPBI) |
FavorableUnfavorable or ambiguousNo Effect |
Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample |
15 years |
300 children | Unadjusted mean = 1.90 | Unadjusted mean = 1.99 | MD = -0.09 | HomVEE calculated = -0.16 | Not statistically significant, p = 0.23 |
Statistical significance is based on HomVEE calculations. |
| High | Parenting practices - Parent involvement: Child Report of Parental Behavior Inventory (CRPBI) |
FavorableUnfavorable or ambiguousNo Effect |
Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample |
15 years |
300 children | Unadjusted mean = 3.34 | Unadjusted mean = 3.33 | MD = 0.01 | HomVEE calculated = 0.02 | Not statistically significant, p = 0.89 |
Statistical significance is based on HomVEE calculations. |
| High | Parenting practices - Supervision: Parenting Style Index measure by Steinberg et al. (1993) |
FavorableUnfavorable or ambiguousNo Effect |
Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample |
15 years |
300 children | Unadjusted mean = 0.86 | Unadjusted mean = 0.89 | MD = -0.03 | HomVEE calculated = -0.26 | Not statistically significant, p = 0.05 |
Statistical significance is based on HomVEE calculations. |
| High | Parenting practices - Warmth: Child Report of Parental Behavior Inventory (CRPBI) |
FavorableUnfavorable or ambiguousNo Effect |
Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample |
15 years |
300 children | Unadjusted mean = 3.65 | Unadjusted mean = 3.67 | MD = -0.02 | HomVEE calculated = -0.04 | Not statistically significant, p = 0.76 |
Statistical significance is based on HomVEE calculations. |