Manuscript Details

Source

Klinnert, M. D., Liu, A. H., Pearson, M. R., Tong, S., Strand, M, Luckow, A., & Robinson, J. L. (2007). Outcome of a randomized multifaceted intervention with low-income families of wheezing infants. Archives of Pediatrics & Adolescent Medicine, 161(8), 783-790.

High rating
Study reviewed under: Handbook of Procedures and Standards, Version 1

Note: Navigate to model page for more information about the home visiting model. See the study manuscript for more information about how the model was implemented in this study.

Author Affiliation

Mary D. Klinnert, a study author, is a developer of this model.

Funding Sources

National Institute of Allergy and Infectious Diseases; National Institute of Health/National Center for Research Resources.

Study Design

Design Attrition Baseline equivalence Confounding factors Valid, reliable measures?
Randomized controlled trial Low

Not applicable

None

Not assessed in manuscripts reviewed under Handbook of Procedures and Standards, Version 1
Notes

High rating applies to oral corticosteroid and emergency department visit outcomes. All other outcomes receive a low rating because of high attrition and failure to demonstrate baseline equivalence.

Study Participants

Participants (infants and their families) were recruited from local hospitals and clinics in the Denver, Colorado, area and assigned randomly to either the intervention or the comparison group. Initially 181 infants were randomly assigned, 90 to the treatment group and 91 to the comparison group. At the four-year-old follow-up that is the focus of the paper, 72 children remained in the intervention group and 77 in the control group. This follow-up sample included European Americans (21 percent treatment, 21 percent control), African American (22 percent treatment, 25 percent control), U.S.-born Hispanic (35 percent treatment, 29 percent control) and foreign-born Hispanic (22 percent treatment, 22 percent control). Approximately half of each group had incomes less than $12,000 per year.

Setting

The study was conducted in Denver, Colorado.

Home Visiting Services

The intervention included home visits conducted by specially trained nurses. The intervention began when infants were from 9 to 24 months old and continued for 12 months. Participants received approximately 15 visits (or telephone calls) by a public health nurse. Each visit lasted an average of 53 minutes.

Note: Navigate to model page for more information about the home visiting model. See the study manuscript for more information about how the model was implemented in this study.

Comparison Conditions

Comparison group members received an educational video at the baseline interview that described risk factors for developing asthma and actions that caregivers can take to mediate the risks.

Subgroups examined

• Asthma symptom severity at baseline (low severity or high severity)

Findings that rate moderate or high in this manuscript

Child health
Outcome measure Timing of follow-up Rating Direction of Effect Effect size (absolute value) Stastical significance Sample size Sample description

Oral corticosteroid use

Between 24 and 34 months

High
0.01

Not statistically significant, p = .44

144 children

Denver, CO sample

Emergency Department Visits

Between 24 and 34 months

High
0.01

Not statistically significant, p = .72

144 children

Denver, CO sample

Effect rating key
Favorable finding / Statistically significant
Unfavorable finding / Statistically significant
Ambiguous finding / Statistically significant
No effect / Not statistically significant

This study included participants with the following characteristics at enrollment:

Race/Ethnicity

The race and ethnicity categories may sum to more than 100 percent if Hispanic ethnicity was reported separately or respondents could select two or more race or ethnicity categories.

Black or African American
24%
Hispanic or Latino
54%
White
21%
Some other race
1%

Maternal Education

Less than a high school diploma
48%
Unknown
52%

Other Characteristics

Data not available