Kitzman, H. J., Olds, D. L., Cole, R. E., Hanks, C. A., Anson, E. A., Arcoleo, K. J., Luckey, D. W., Knudtson, M. D., Henderson, C. R., & Holmberg, J. R. (2010). Enduring effects of prenatal and infancy home visiting by nurses on children: Follow-up of a randomized trial among children at age 12 years. Archives of Pediatrics & Adolescent Medicine, 164(5), 412–418.
| Screening decision | Screening conclusion | HomVEE procedures and standards version |
|---|---|---|
| Passes screens | Eligible for review | Version 1 |
| Rating | Design | Attrition | Baseline equivalence | Compromised randomization | Confounding factors | Valid, reliable measure(s) |
|---|---|---|---|---|---|---|
| High | Randomized controlled trial | Low | Established for race/ethnicity. Significant differences in SES, but controlled in analyses. | None | None | Not assessed in manuscripts reviewed before 2021 |
In 2020, HomVEE updated this review in two ways. First, HomVEE moved six findings on externalizing disorders, internalizing disorders, and total problems from the Reductions in Juvenile Delinquency, Family Violence, and Crime domain to the Child Development and School Readiness domain. Second, HomVEE moved the findings on whether the child used cigarettes, alcohol, or marijuana in the past 30 days from the Child Health domain to the Child Development and School Readiness domain. These changes are because ACF determined that all measures of child behavioral health, including internalizing and externalizing behaviors and children's risky behaviors, belong in HomVEE's Child Development and School Readiness domain.
| Study participants | From June 1, 1990 through August 31, 1991, the study enrolled primarily African American women at fewer than 29 weeks of gestation, with no previous live births, and with at least 2 of the following sociodemographic risk characteristics:unmarried, fewer than 12 years of education, and unemployed. Of the 1,290 eligible women, 1,139 consented and were randomly assigned. A subset of 743 women were involved in the postnatal aspect of the trial. Of the women enrolled, 92.1% were African American, 98.1% were unmarried, 64.1% were 18 years or younger at registration, and 85.1% came from households with annual incomes below the U.S. federal poverty guidelines. This study focused on the 12-year follow up; 594 women completed a maternal interview and 578 children completed an interview. |
|---|---|
| Setting | Memphis, TN |
| Intervention services | Women in the nurse-visited group were provided the same services as those in the comparison group, plus home visitation from pregnancy through the child’s second birthday. The nurses were provided detailed guidelines for each visit but allowed to adapt them to the needs of individual families. The nurses also linked families to other health and human services and tried to involve the children’s fathers and grandmothers in the pregnancy and care of the child. Each nurse visited a maximum of 25 families. The program is intended to provide 62 home visits for women who enroll at 16 weeks gestation. In this study, the nurses completed a mean of 7 home visits (range of 0 to 18) during pregnancy and 26 home visits (range of 0 to 71) during the first 2 years after birth. Generally the difference between the recommended and actual number of visits was the result of participants dropping out of the program. |
| Comparison conditions | Women in the comparison group were provided developmental screening and referrals for the child at 6, 12, and 24 months of age, and free transportation for scheduled prenatal care. |
| Subgroups examined |
This field lists subgroups examined in the manuscript (even if they were not replicated in other samples and not reported on the summary page for this model’s report). • Mother has psychological vulnerability (yes or no) |
| Funding sources | This project was supported by National Institutes of Health research grant 1R01MH68790-01 funded by the National Institute of Mental Health and the Office of Juvenile Justice and Delinquency Prevention grant 2004-52854-CO-JS0. The earlier phases of this study were supported by several federal agencies: the National Institute of Mental Health (grant R01-MH61428- 01), the National Institute of Child Health and Human Development (grant R01-HD-043492), the National Institute of Nursing Research (grant NR01-01691-05), the Bureau of Maternal and Child Health (grant MCJ 360579), the Administration for Children and Families (grants 90PJ0003 and 90PD0215/01), the Office of the Assistant Secretary for Planning and Evaluation (Department of Health and Human Services), and the National Center for Child Abuse and Neglect through a transfer of funds to the National Institute of Nursing Research (grant R01NR01691). The earlier phases of this research also were supported by 5 private foundations: the Robert Wood Johnson Foundation (grants 017934 and 11084), the Carnegie Corporation of New York (grant B 5492), the Pew Charitable Trusts (grants 88-0211-000 and 93-02363-000), the William T. Grant Foundation (grants 88-1246-88 and 91-1246-88), and the Hearst Foundation, as well as a Senior Research Scientist Award from the National Institutes of Health (1-K05-MH01382-01) (Dr Olds). |
| Author affiliation | David L. Olds, a study author, is a developer of this model. |
| Peer reviewed | Peer reviewed status is not listed for manuscripts reviewed before 2021. |
| Rating | Outcome measure | Effect | Sample | Timing of follow-up | Sample size | Intervention group | Comparison group | Group difference | Effect size | Statistical significance | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| High | GPA (reading and math) (grades 1-6) | FavorableUnfavorable or ambiguousNo Effect |
Mothers with low psychological resources — Nurse home visitors and comparison (Memphis) | 12-year follow-up | 326 mothers | Mean = 2.46 | Mean = 2.27 | Mean difference = 0.20 | HomVEE calculated = 3.32 | Statistically significant, p < .05 | footnote121Outcome examined with repeated measures. |
| High | GPA (reading and math) (grades 4-6) | FavorableUnfavorable or ambiguousNo Effect |
Mothers with low psychological resources — Nurse home visitors and comparison (Memphis) | 12-year follow-up | 326 mothers | Mean = 2.27 | Mean = 2.08 | Mean difference = 0.19 | HomVEE calculated = 2.83 | Statistically significant, p < .05 | footnote121Outcome examined with repeated measures. |
| High | PIAT scores (reading and math) at 12 years | FavorableUnfavorable or ambiguousNo Effect |
Mothers with low psychological resources — Nurse home visitors and comparison (Memphis) | 12-year follow-up | 326 mothers | Mean = 88.78 | Mean = 85.70 | Mean difference = 3.07 | HomVEE calculated = 3.91 | Statistically significant, p < .05 | footnote121Outcome examined with repeated measures. |
| High | Conduct grades (grades 1-6) | FavorableUnfavorable or ambiguousNo Effect |
Mothers with low psychological resources — Nurse home visitors and comparison (Memphis) | 12-year follow-up | 326 mothers | Mean = 2.93 | Mean = 2.86 | Mean difference = 0.07 | HomVEE calculated = 1.61 | Not statistically significant, p ≥ 0.05 | footnote121Outcome examined with repeated measures. |
| High | Conduct grades (grades 4-6) | FavorableUnfavorable or ambiguousNo Effect |
Mothers with low psychological resources — Nurse home visitors and comparison (Memphis) | 12-year follow-up | 326 mothers | Mean = 2.91 | Mean = 2.86 | Mean difference = 0.05 | HomVEE calculated = 0.93 | Not statistically significant, p ≥ 0.05 | footnote121Outcome examined with repeated measures. |
| High | Ever placed in special education (grades 1-6) | FavorableUnfavorable or ambiguousNo Effect |
Mothers with low psychological resources — Nurse home visitors and comparison (Memphis) | 12-year follow-up | 326 mothers | % = 15.00 | % = 15.00 | OR = 0.97 | HomVEE calculated = -0.02 | Not statistically significant, p ≥ 0.05 | footnote122Percentages adjusted for covariates in the model (household poverty and maternal childrearing attitudes). |
| High | Ever retained | FavorableUnfavorable or ambiguousNo Effect |
Mothers with low psychological resources — Nurse home visitors and comparison (Memphis) | 12-year follow-up | 326 mothers | % = 23.00 | % = 27.00 | OR = 0.77 | HomVEE calculated = -0.16 | Not statistically significant, p ≥ 0.05 | footnote122Percentages adjusted for covariates in the model (household poverty and maternal childrearing attitudes). |
| High | Externalizing disorders | FavorableUnfavorable or ambiguousNo Effect |
Mothers with low psychological resources — Nurse home visitors and comparison (Memphis) | 12 years | 326 mothers | % (adjusted) = 24.00 | Adjusted mean % = 22.00 | OR = 1.12 | HomVEE calculated = 0.07 | Not statistically significant, p ≥ 0.05 | |
| High | Group achievement test scores (reading and math) (grades 1-6), percentile1 | FavorableUnfavorable or ambiguousNo Effect |
Mothers with low psychological resources — Nurse home visitors and comparison (Memphis) | 12-year follow-up | 326 mothers | Mean = 40.52 | Mean = 34.85 | Mean difference = 5.67 | HomVEE calculated = 3.39 | Statistically significant, p < .05 | |
| High | Group achievement test scores (reading and math) (grades 4-6), percentile1 | FavorableUnfavorable or ambiguousNo Effect |
Mothers with low psychological resources — Nurse home visitors and comparison (Memphis) | 12-year follow-up | 326 mothers | Mean = 36.86 | Mean = 33.67 | Mean difference = 3.19 | HomVEE calculated = 1.87 | Not statistically significant, p ≥ 0.05 | |
| High | Internalizing disorders | FavorableUnfavorable or ambiguousNo Effect |
Mothers with low psychological resources — Nurse home visitors and comparison (Memphis) | 12 years | 326 mothers | %(adjusted) = 32.00 | Adjusted mean % = 36.00 | OR = 0.81 | HomVEE calculated = -0.13 | Not statistically significant, p ≥ 0.05 | |
| High | Leiter-R Sustained Attention test scaled score | FavorableUnfavorable or ambiguousNo Effect |
Mothers with low psychological resources — Nurse home visitors and comparison (Memphis) | 12-year follow-up | 326 mothers | Mean = 8.63 | Mean = 8.72 | Mean difference = -0.09 | HomVEE calculated = -0.39 | Not statistically significant, p ≥ 0.05 | |
| High | Total problems | FavorableUnfavorable or ambiguousNo Effect |
Mothers with low psychological resources — Nurse home visitors and comparison (Memphis) | 12 years | 326 mothers | % (adjusted = 30.00 | Adjusted mean % = 27.00 | OR = 1.17 | HomVEE calculated = 0.09 | Not statistically significant, p ≥ 0.05 | |
| High | GPA (reading and math) (grades 1–6) | FavorableUnfavorable or ambiguousNo Effect |
Nurse visited during pregnancy + infancy and development screening comparison (Memphis) | 12-year follow-up | 635 children | Mean = 2.48 | Mean = 2.39 | Mean difference = 0.09 | HomVEE calculated = 2.07 | Not statistically significant, p ≥ 0.05 | footnote121Outcome examined with repeated measures. |
| High | GPA (reading and math) (grades 4–6) | FavorableUnfavorable or ambiguousNo Effect |
Nurse visited during pregnancy + infancy and development screening comparison (Memphis) | 12-year follow-up | 635 children | Mean = 2.28 | Mean = 2.20 | Mean difference = 0.08 | HomVEE calculated = 1.70 | Not statistically significant, p ≥ 0.05 | footnote121Outcome examined with repeated measures. |
| High | PIAT scores (reading and math) at 12 years | FavorableUnfavorable or ambiguousNo Effect |
Nurse visited during pregnancy + infancy and development screening comparison (Memphis) | 12-year follow-up | 568 children | Mean = 89.24 | Mean = 87.96 | Mean difference = 1.27 | HomVEE calculated = 2.25 | Not statistically significant, p ≥ 0.05 | footnote121Outcome examined with repeated measures. |
| High | Conduct grades (grades 1–-6) | FavorableUnfavorable or ambiguousNo Effect |
Nurse visited during pregnancy + infancy and development screening comparison (Memphis) | 12-year follow-up | 635 children | Mean = 2.95 | Mean = 2.89 | Mean difference = 0.06 | HomVEE calculated = 1.79 | Not statistically significant, p ≥ 0.05 | |
| High | Conduct grades (grades 4–6) | FavorableUnfavorable or ambiguousNo Effect |
Nurse visited during pregnancy + infancy and development screening comparison (Memphis) | 12-year follow-up | 635 children | Mean = 2.95 | Mean = 2.88 | Mean difference = 0.07 | HomVEE calculated = 1.87 | Not statistically significant, p ≥ 0.05 | footnote121Outcome examined with repeated measures. |
| High | Ever placed in special education (grades 1–6) | FavorableUnfavorable or ambiguousNo Effect |
Nurse visited during pregnancy + infancy and development screening comparison (Memphis) | 12-year follow-up | 635 children | % (adjusted) = 14.80 | Adjusted mean % = 9.80 | OR = 1.61 | HomVEE calculated = 0.28 | Not statistically significant, p ≥ 0.05 | |
| High | Ever retained | FavorableUnfavorable or ambiguousNo Effect |
Nurse visited during pregnancy + infancy and development screening comparison (Memphis) | 12-year follow-up | 635 children | % (adjusted) = 24.90 | Adjusted mean % = 20.80 | OR = 1.26 | HomVEE calculated = 0.14 | Not statistically significant, p ≥ 0.05 | |
| High | Group achievement test scores (reading and math) (grades 1–6), percentile | FavorableUnfavorable or ambiguousNo Effect |
Nurse visited during pregnancy + infancy and development screening comparison (Memphis) | 12-year follow-up | 578 children | Mean = 42.34 | Mean = 39.79 | Mean difference = 2.55 | HomVEE calculated = 2.12 | Not statistically significant, p ≥ 0.05 | footnote121Outcome examined with repeated measures. |
| High | Group achievement test scores (reading and math) (grades 4–6), percentile | FavorableUnfavorable or ambiguousNo Effect |
Nurse visited during pregnancy + infancy and development screening comparison (Memphis) | 12-year follow-up | 635 children | Mean = 39.37 | Mean = 38.27 | Mean difference = 1.09 | HomVEE calculated = 0.89 | Not statistically significant, p ≥ 0.05 | footnote121Outcome examined with repeated measures. |
| High | Leiter-R Sustained Attention test scaled score | FavorableUnfavorable or ambiguousNo Effect |
Nurse visited during pregnancy + infancy and development screening comparison (Memphis) | 12-year follow-up | 578 children | Mean = 8.68 | Mean = 8.75 | Mean difference = -0.07 | HomVEE calculated = -0.42 | Not statistically significant, p ≥ 0.05 | |
| High | Externalizing disorders | FavorableUnfavorable or ambiguousNo Effect |
Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) | 12 years | 594 mothers, 578 children, and 548 teachers | % (adjusted) = 19.70 | Adjusted mean % = 17.80 | OR = 1.13 | HomVEE calculated = 0.08 | Not statistically significant, p ≥ 0.05 | |
| High | Incidence of days of substance use in the past 30 days | FavorableUnfavorable or ambiguousNo Effect |
Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) | 12 years | 578 children | = 0.03 | = 0.18 | IR = 0.15 | Not available | Statistically significant, p < .05 | |
| High | Internalizing disorders | FavorableUnfavorable or ambiguousNo Effect |
Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) | 12 years | 578 children | %(adjusted) = 22.10 | Adjusted mean % = 30.90 | OR = 0.63 | HomVEE calculated = -0.28 | Statistically significant, p < .05 | |
| High | Number of substances used in the past 30 days | FavorableUnfavorable or ambiguousNo Effect |
Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) | 12 years | 578 children | = 0.02 | = 0.08 | IR = 0.06 | Not available | Statistically significant, p < .05 | |
| High | Total problems | FavorableUnfavorable or ambiguousNo Effect |
Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) | 12 years | 594 mothers, 578 children, and 548 teachers | % (adjusted) = 23.70 | Adjusted mean % = 19.80 | OR = 1.26 | HomVEE calculated = 0.14 | Not statistically significant, p ≥ 0.05 | |
| High | Used cigarettes, alcohol, or marijuana in the past 30 days | FavorableUnfavorable or ambiguousNo Effect |
Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) | 12 years | 578 children | %(adjusted) = 1.70 | Adjusted mean % = 5.10 | OR = 0.31 | HomVEE calculated = -0.69 | Statistically significant, p < .05 |
| Rating | Outcome measure | Effect | Sample | Timing of follow-up | Sample size | Intervention group | Comparison group | Group difference | Effect size | Statistical significance | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| High | Ever arrested | FavorableUnfavorable or ambiguousNo Effect |
Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) | 12 years | 594 mothers and 578 children | % (adjusted) = 3.10 | Adjusted mean % = 3.10 | Difference = 0.00 | HomVEE calculated = 0.00 | Not statistically significant |
