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Enoch, M. A., Kitzman, H., Smith, J. A., Anson, E., Hodgkinson, C. A., Goldman, D., & Olds, D. L. (2016). A prospective cohort study of influences on externalizing behaviors across childhood: Results from a nurse home visiting randomized controlled trial. Journal of the American Academy of Child and Adolescent Psychiatry, 55(5), 376–382.

Manuscript screening details
Screening decision Screening conclusion HomVEE procedures and standards version
Passes screens Eligible for review Version 1
Study design details
Rating Design Attrition Baseline equivalence Compromised randomization Confounding factors Valid, reliable measure(s)
High Randomized controlled trial Low Established on race/ethnicity and SES; outcomes not feasible to assess at baseline None None Not assessed in manuscripts reviewed before 2021
Study characteristics
Study participants Participants were firstborn children of predominantly African-American mothers in Memphis, TN, who participated in a randomized controlled trial study of the Nurse Family Partnership (NFP) model beginning in 1991. Eligible participants were less than 29 weeks pregnant when they enrolled, had never delivered a live birth, and had two or more of the following risk factors: unmarried, less than 12 years of education, and/or unemployed. For the current study, the treatment group had 186 mothers and the comparison group had 414 mothers. At baseline, 94 percent of mothers in the sample identified as African-American and the average maternal age was 18.1 years. On average, 36 percent of the treatment group was living below the poverty level.
Setting Memphis, TN
Intervention services Mothers assigned to the NFP treatment group received regular nurse home visits starting in pregnancy and ending when the child turned 2 years old. Mothers in the treatment group also received the same services as the comparison group.
Comparison conditions Mothers in the comparison group received free transportation to scheduled prenatal care appointments and screening and referral services for their child.
Subgroups examined This field lists subgroups examined in the manuscript (even if they were not replicated in other samples and not reported on the summary page for this model’s report).

• Maternal self-efficacy (has high self-efficacy)

Funding sources This study was supported with funding from the Robert Wood Johnson Foundation, the Carnegie Corporation of New York, the Pew Charitable Trusts, the William T. Grant Foundation, and an NIH Senior Research Scientist Award to Dr. Olds (1-K05-MH01382-01).
Author affiliation David L. Olds, one of the study authors, is also the model developer.
Peer reviewed Peer reviewed status is not listed for manuscripts reviewed before 2021.
Study Registration:

Clinicaltrials.gov Identifier: None found. Study registration was assessed by HomVEE beginning with the 2014 review.

Findings that rate moderate or high

Child development and school readiness
Rating Outcome measure Effect Sample Timing of follow-up Sample size Intervention group Comparison group Group difference Effect size Statistical significance Notes
High

Composite externalizing disorders (ED) continuous total scores: Achenbach Child Behavior Checklist (CBCL) (12-year follow-up)

FavorableUnfavorable or ambiguousNo Effect

Nurse home-visited vs. comparison, Memphis sample

12 years

559 children Not reported Not reported Not reported Not available

Not statistically significant, p ≥ 0.05

Statistical significance is based on information the authors provided in the text.

High

Composite externalizing disorders (ED) continuous total scores: Achenbach Child Behavior Checklist (CBCL) (2-year follow-up)

FavorableUnfavorable or ambiguousNo Effect

Nurse home-visited vs. comparison, Memphis sample

2 years

587 children Not reported Not reported Not reported Not available

Statistically significant, p = 0.03

Statistical significance and favorability are based on information the authors provided in the text.

High

Composite externalizing disorders (ED) continuous total scores: Achenbach Child Behavior Checklist (CBCL) (6-year follow-up)

FavorableUnfavorable or ambiguousNo Effect

Nurse home-visited vs. comparison, Memphis sample

6 years

575 children Not reported Not reported Not reported Not available

Not statistically significant, p ≥ 0.05

Statistical significance is based on information the authors provided in the text.