Manuscript Detail | Home Visiting Evidence of Effectiveness

Izzo, C., Eckenrode, J., Smith, E., Henderson, C., Cole, R., Kitzman, H., & Olds, D. L. (2005). Reducing the impact of uncontrollable stressful life events through a program of nurse home visitation for new parents. Prevention Science, 6(4), 269–274.

Manuscript screening details
Screening decision	Screening conclusion	HomVEE procedures and standards version
Passes screens	Eligible for review	Version 1

Study design details
Rating	Design	Attrition	Baseline equivalence	Compromised randomization	Confounding factors	Valid, reliable measure(s)
High	Randomized controlled trial	Low	Established on race/ethnicity and SES; outcomes not feasible to assess at baseline	None	None	Not assessed in manuscripts reviewed before 2021

Notes:

In addition to the outcomes that received a high rating, substance use outcomes in the maternal health domain received a moderate rating because equivalence was not established on baseline measures of the outcomes.

Study characteristics
Study participants	Participants were 324 mothers and 315 of their first-born children. The mothers and children all participated in an RCT examining the Nurse-Family Partnership model in Elmira, NY in 1978. At the time of recruitment, participants were pregnant, first-time mothers who were less than 25 weeks pregnant. All participants were all either under the age of 19; unmarried; or had low socioeconomic status, as indicated by their Medicaid eligibility.
Setting	Elmira, NY, USA
Intervention services	The treatment group received in-home nurse visits from pregnancy through 24 months after birth, in addition to the same services as the comparison group.
Comparison conditions	Mothers in the comparison group received developmental and sensory screening for their children, clinical referrals, and transportation to prenatal and postnatal care.
Subgroups examined	This field lists subgroups examined in the manuscript (even if they were not replicated in other samples and not reported on the summary page for this model’s report). Subgroups are not listed for manuscripts reviewed before 2021.
Funding sources	This study was supported with grants from the Prevention Research Branch of the National Institutes of Mental Health (R01-MH49381); the Assistant Secretary for Planning and Evaluation, U.S. Department of Health and Human Services (96ASPE278A); the Children's Bureau, U.S. Department of Health and Human Services (90-CA-1631). The research was also supported by an NIH Senior Research Scientist Award.
Author affiliation	David L. Olds, one of the study authors, is also the model developer.
Peer reviewed	Peer reviewed status is not listed for manuscripts reviewed before 2021.

Study Registration:

Clinicaltrials.gov Identifier: None found. Study registration was assessed by HomVEE beginning with the 2014 review.

Findings that rate moderate or high

Maternal health
Rating	Outcome measure	Effect	Sample	Timing of follow-up	Sample size	Intervention group	Comparison group	Group difference	Effect size	Statistical significance	Notes
High	Mental health - Anxiety: Mental Health Inventory (MHI)	FavorableUnfavorable or ambiguousNo Effect	Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample	15 years	300 mothers	Unadjusted mean = 2.56	Unadjusted mean = 2.56	MD = 0.00	HomVEE calculated = 0.00	Not statistically significant, p = 1.00	HomVEE calculated significance Submitted by nwu on Fri, 04/12/2019 - 18:31 Statistical significance is based on HomVEE calculations.
High	Mental health - Depression: Mental Health Inventory (MHI)	FavorableUnfavorable or ambiguousNo Effect	Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample	15 years	300 mothers	Unadjusted mean = 2.01	Unadjusted mean = 2.02	MD = -0.01	HomVEE calculated = -0.01	Not statistically significant, p = 0.95	HomVEE calculated significance Submitted by nwu on Fri, 04/12/2019 - 18:31 Statistical significance is based on HomVEE calculations.
High	Mental health - Emotional stability: Mental Health Inventory (MHI)	FavorableUnfavorable or ambiguousNo Effect	Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample	15 years	300 mothers	Unadjusted mean = 3.75	Unadjusted mean = 3.74	MD = 0.01	HomVEE calculated = 0.02	Not statistically significant, p = 0.90	HomVEE calculated significance Submitted by nwu on Fri, 04/12/2019 - 18:31 Statistical significance is based on HomVEE calculations.
High	Mental health - Positive well-being: Mental Health Inventory (MHI)	FavorableUnfavorable or ambiguousNo Effect	Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample	15 years	300 mothers	Unadjusted mean = 3.78	Unadjusted mean = 3.79	MD = -0.01	HomVEE calculated = -0.02	Not statistically significant, p = 0.90	HomVEE calculated significance Submitted by nwu on Fri, 04/12/2019 - 18:31 Statistical significance is based on HomVEE calculations.
Moderate	Alcohol impairment score	FavorableUnfavorable or ambiguousNo Effect	Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample	15 years	300 mothers	Unadjusted mean = 0.35	Unadjusted mean = 0.37	MD = -0.02	HomVEE calculated = -0.02	Not statistically significant, p = 0.87	HomVEE calculated significance Submitted by nwu on Fri, 04/12/2019 - 18:31 Statistical significance is based on HomVEE calculations.
Moderate	Substance use - # cigarettes smoked per day	FavorableUnfavorable or ambiguousNo Effect	Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample	15 years	300 mothers	Unadjusted mean = 8.32	Unadjusted mean = 10.56	MD = -2.24	HomVEE calculated = -0.21	Not statistically significant, p = 0.11	HomVEE calculated significance Submitted by nwu on Fri, 04/12/2019 - 18:31 Statistical significance is based on HomVEE calculations.
Moderate	Substance use - binge drinking: # days had 5+ drinks in the past year	FavorableUnfavorable or ambiguousNo Effect	Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample	15 years	300 mothers	Unadjusted mean = 11.70	Unadjusted mean = 9.27	MD = 2.43	HomVEE calculated = 0.06	Not statistically significant, p = 0.65	HomVEE calculated significance Submitted by nwu on Fri, 04/12/2019 - 18:31 Statistical significance is based on HomVEE calculations.

Positive parenting practices
Rating	Outcome measure	Effect	Sample	Timing of follow-up	Sample size	Intervention group	Comparison group	Group difference	Effect size	Statistical significance	Notes
High	Parenting practices - Hostility: Child Report of Parental Behavior Inventory (CRPBI)	FavorableUnfavorable or ambiguousNo Effect	Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample	15 years	300 children	Unadjusted mean = 1.38	Unadjusted mean = 1.99	MD = -0.61	HomVEE calculated = -1.22	Statistically significant, p = 0.00	HomVEE calculated significance Submitted by nwu on Fri, 04/12/2019 - 18:31 Statistical significance is based on HomVEE calculations. Negative effect is favorable Submitted by user on Fri, 03/15/2019 - 14:29 Negative effect is favorable to the intervention.
High	Parenting practices - Inconsistent discipline: Child Report of Parental Behavior Inventory (CRPBI)	FavorableUnfavorable or ambiguousNo Effect	Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample	15 years	300 children	Unadjusted mean = 1.90	Unadjusted mean = 1.99	MD = -0.09	HomVEE calculated = -0.16	Not statistically significant, p = 0.23	HomVEE calculated significance Submitted by nwu on Fri, 04/12/2019 - 18:31 Statistical significance is based on HomVEE calculations.
High	Parenting practices - Parent involvement: Child Report of Parental Behavior Inventory (CRPBI)	FavorableUnfavorable or ambiguousNo Effect	Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample	15 years	300 children	Unadjusted mean = 3.34	Unadjusted mean = 3.33	MD = 0.01	HomVEE calculated = 0.02	Not statistically significant, p = 0.89	HomVEE calculated significance Submitted by nwu on Fri, 04/12/2019 - 18:31 Statistical significance is based on HomVEE calculations.
High	Parenting practices - Supervision: Parenting Style Index measure by Steinberg et al. (1993)	FavorableUnfavorable or ambiguousNo Effect	Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample	15 years	300 children	Unadjusted mean = 0.86	Unadjusted mean = 0.89	MD = -0.03	HomVEE calculated = -0.26	Not statistically significant, p = 0.05	HomVEE calculated significance Submitted by nwu on Fri, 04/12/2019 - 18:31 Statistical significance is based on HomVEE calculations.
High	Parenting practices - Warmth: Child Report of Parental Behavior Inventory (CRPBI)	FavorableUnfavorable or ambiguousNo Effect	Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample	15 years	300 children	Unadjusted mean = 3.65	Unadjusted mean = 3.67	MD = -0.02	HomVEE calculated = -0.04	Not statistically significant, p = 0.76	HomVEE calculated significance Submitted by nwu on Fri, 04/12/2019 - 18:31 Statistical significance is based on HomVEE calculations.