Nurse-Family Partnership (NFP)® Meets HHS Criteria

Model effectiveness research report last updated: 2019

Effects shown in research

Child health

Findings rated high

NFP with Paraprofessional Home Visitors - Mothers with low psychological resources subgroup
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance Notes
5-minute Apgar
FavorableUnfavorable or ambiguousNo Effect
Birth Full, (Memphis) 1082 children Adjusted mean = 8.60 Adjusted mean = 8.70 Mean difference = -0.10 Not available Not statistically significant,
p > 0.05
Birth weight, grams
FavorableUnfavorable or ambiguousNo Effect
Birth Full (Memphis) 1082 children Adjusted mean = 3032.20 Adjusted mean = 3050.40 Mean difference = -18.20 Not available Not statistically significant,
p > 0.05
Breastfeeding attempted, percentage
FavorableUnfavorable or ambiguousNo Effect
2 years postnatal Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 671 children % (adjusted) = 26.00 Adjusted mean % = 16.00 OR = 1.90 HomVEE calculated = 0.37 Statistically significant,
p < 0.01

footnote6

Submitted by user on

The odds ratio compares the nurse-visited group to the comparison.

Gestational age, weeks
FavorableUnfavorable or ambiguousNo Effect
Birth Full, (Memphis) 1082 children Adjusted mean = 39.00 Adjusted mean = 39.00 Mean difference = 0.00 Not available Not statistically significant,
p > 0.05
Immunizations up to date, percentage
FavorableUnfavorable or ambiguousNo Effect
2 years postnatal Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 671 children % (adjusted) = 70.00 Adjusted mean % = 68.00 OR = 1.10 HomVEE calculated = 0.06 Not statistically significant,
p > 0.05

footnote6

Submitted by user on

The odds ratio compares the nurse-visited group to the comparison.

Indicated preterm delivery (percentage)
FavorableUnfavorable or ambiguousNo Effect
Birth Full, (Memphis) 1082 children % (adjusted) = 3.00 Adjusted mean % = 3.00 OR = 1.00 HomVEE calculated = 0.00 Not statistically significant,
p > 0.05

footnote2

Submitted by user on

Statistical significance reported on authors’ calculations of the odds ratio.

footnote6

Submitted by user on

The odds ratio compares the nurse-visited group to the comparison.

Intrauterine growth restriction (percentage)
FavorableUnfavorable or ambiguousNo Effect
Birth Full, (Memphis) 1082 children % (adjusted) = 9.00 Adjusted mean % = 9.00 OR = 1.00 HomVEE calculated = 0.00 Not statistically significant,
p > 0.05

footnote2

Submitted by user on

Statistical significance reported on authors’ calculations of the odds ratio.

footnote6

Submitted by user on

The odds ratio compares the nurse-visited group to the comparison.

Low birth weight (percentage < 2500 g)
FavorableUnfavorable or ambiguousNo Effect
Birth Full, (Memphis) 1082 children % (adjusted) = 15.00 Adjusted mean % = 14.00 OR = 1.10 HomVEE calculated = 0.05 Not statistically significant,
p > 0.05

footnote2

Submitted by user on

Statistical significance reported on authors’ calculations of the odds ratio.

footnote6

Submitted by user on

The odds ratio compares the nurse-visited group to the comparison.

Number of well-child visits
FavorableUnfavorable or ambiguousNo Effect
2 years postnatal Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 671 children Adjusted mean = 4.60 Adjusted mean = 4.80 Mean difference = -0.20 Not available Not statistically significant,
p > 0.05
Preterm (less than 37 weeks, percentage)
FavorableUnfavorable or ambiguousNo Effect
Birth Full, (Memphis) 1082 children % (adjusted) = 11.00 Adjusted mean % = 13.00 OR = 0.80 HomVEE calculated = -0.12 Not statistically significant,
p > 0.05

footnote2

Submitted by user on

Statistical significance reported on authors’ calculations of the odds ratio.

footnote6

Submitted by user on

The odds ratio compares the nurse-visited group to the comparison.

Spontaneous preterm delivery, percentage
FavorableUnfavorable or ambiguousNo Effect
Birth Full, (Memphis) 1082 children % (adjusted) = 8.00 Adjusted mean % = 9.00 OR = 0.80 HomVEE calculated = -0.08 Not statistically significant,
p > 0.05

footnote2

Submitted by user on

Statistical significance reported on authors’ calculations of the odds ratio.

footnote6

Submitted by user on

The odds ratio compares the nurse-visited group to the comparison.

NFP with Paraprofessional Home Visitors - Mothers with low psychological resources subgroup
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance Notes
Number of subsequent low birth weight newborns (< 2500 g)
FavorableUnfavorable or ambiguousNo Effect
3-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 646 mothers Mean = 0.12 Mean = 0.15 Mean difference = -0.03 Not available Not statistically significant,
p ≥ 0.05

footnote1

Submitted by user on

Statistical significance reported on authors’ calculations of the log-incidence difference.

Number of subsequent neonatal intensive care unit or special care admissions
FavorableUnfavorable or ambiguousNo Effect
3-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 646 mothers Mean = 0.14 Mean = 0.20 Mean difference = -0.06 Not available Not statistically significant,
p ≥ 0.05

footnote1

Submitted by user on

Statistical significance reported on authors’ calculations of the log-incidence difference.

footnote3

Submitted by user on

Authors report the difference in this outcome to be statistically significant, p < 0.10, which is greater than the acceptable alpha for this review (&alpha; = 0.05).

NFP with Paraprofessional Home Visitors - Mothers with low psychological resources subgroup
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance
Night awake (mother-reported number of episodes last 2 weeks
FavorableUnfavorable or ambiguousNo Effect
6 months Nurse visited during pregnancy + infancy and comparison (Elmira) 163 children Adjusted mean = 2.69 Adjusted mean = 2.83 Mean difference = -0.14 Not available Not statistically significant,
p > 0.05
Night awake (mother-reported number of episodes last 2 weeks
FavorableUnfavorable or ambiguousNo Effect
6 months Nurse visited during pregnancy and comparison (Elmira) 164 children Adjusted mean = 3.25 Adjusted mean = 2.83 Mean difference = 0.42 Not available Statistical significance not reported
Number of emergency room visits (first year of life)
FavorableUnfavorable or ambiguousNo Effect
1-year follow-up Nurse visited during pregnancy and comparison (Elmira) 205 children Adjusted mean = 1.12 Adjusted mean = 1.02 Mean difference = 0.10 Not available Statistical significance not reported
Number of emergency room visits (first year of life)
FavorableUnfavorable or ambiguousNo Effect
1-year follow-up Nurse visited during pregnancy + infancy and comparison (Elmira) 223 children Adjusted mean = 0.74 Adjusted mean = 1.02 Mean difference = -0.28 Not available Statistically significant,
p < 0.05
Number of emergency room visits (second year of life)
FavorableUnfavorable or ambiguousNo Effect
2-year follow-up Nurse visited during pregnancy and comparison (Elmira) 185 children Adjusted mean = 1.04 Adjusted mean = 1.09 Mean difference = -0.05 Not available Statistical significance not reported
Number of emergency room visits (second year of life)
FavorableUnfavorable or ambiguousNo Effect
2-year follow-up Nurse visited during pregnancy + infancy and comparison (Elmira) 196 children Adjusted mean = 0.74 Adjusted mean = 1.09 Mean difference = -0.35 Not available Statistically significant,
p < 0.01
Resist eating (mother-reported number of episodes last 2 weeks)
FavorableUnfavorable or ambiguousNo Effect
6 months Nurse visited during pregnancy and comparison (Elmira) 164 children Adjusted mean = 2.01 Adjusted mean = 1.72 Mean difference = 0.29 Not available Statistical significance not reported
Resist eating (mother-reported number of episodes last 2 weeks)
FavorableUnfavorable or ambiguousNo Effect
6 months Nurse visited during pregnancy + infancy and comparison (Elmira) 163 children Adjusted mean = 2.29 Adjusted mean = 1.72 Mean difference = 0.57 Not available Statistically significant,
p < 0.01
NFP with Paraprofessional Home Visitors - Mothers with low psychological resources subgroup
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance
Child birth weight (grams)
FavorableUnfavorable or ambiguousNo Effect
Birth Full (Elmira) 308 children Adjusted mean = 3285.00 Adjusted mean = 3262.00 Mean difference = 23.00 Not available Not statistically significant,
p > 0.05
Length of gestation
FavorableUnfavorable or ambiguousNo Effect
Birth Full (Elmira) 308 children Adjusted mean = 39.57 Adjusted mean = 39.71 Mean difference = -0.14 Not available Not statistically significant,
p > 0.05
Percentage low birth rate, (≤ 2,500 grams)
FavorableUnfavorable or ambiguousNo Effect
Birth Full (Elmira) 308 children % (adjusted) = 5.78 Adjusted mean % = 2.61 Mean difference = 3.17 HomVEE calculated = 0.50 Not statistically significant,
p > 0.05
Percentage preterm delivery (< 37 weeks)
FavorableUnfavorable or ambiguousNo Effect
Birth Full (Elmira) 308 children % (adjusted) = 6.90 Adjusted mean % = 7.27 Mean difference = -0.37 HomVEE calculated = -0.03 Not statistically significant,
p > 0.05
NFP with Paraprofessional Home Visitors - Mothers with low psychological resources subgroup
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance Notes
Number of days hospitalized (25 to 50 months)
FavorableUnfavorable or ambiguousNo Effect
50 months Nurse visited during pregnancy + infancy and comparison (Elmira) 221 children Adjusted mean = 0.49 Adjusted mean = 0.31 Mean difference = 0.18 Not available Statistically significant,
p ≤ 0.05

footnote1

Submitted by user on

Statistical significance reported on authors’ calculations of the log-incidence difference.

Number of days hospitalized (25 to 50 months)
FavorableUnfavorable or ambiguousNo Effect
50 months Nurse visited during pregnancy and comparison (Elmira) 209 children Adjusted mean = 0.43 Adjusted mean = 0.31 Mean difference = 0.12 Not available Statistical significance not reported
Number of emergency department visits (25 to 50 months)
FavorableUnfavorable or ambiguousNo Effect
50 months Nurse visited during pregnancy + infancy and comparison (Elmira) 221 children Adjusted mean = 1.00 Adjusted mean = 1.53 Mean difference = -0.53 Not available Statistically significant,
p ≤ .01

footnote1

Submitted by user on

Statistical significance reported on authors’ calculations of the log-incidence difference.

Number of emergency department visits (25 to 50 months)
FavorableUnfavorable or ambiguousNo Effect
50 months Nurse visited during pregnancy and comparison (Elmira) 209 children Adjusted mean = 1.24 Adjusted mean = 1.53 Mean difference = -0.29 Not available Statistical significance not reported
Number of hospital admissions (25 to 50 months)
FavorableUnfavorable or ambiguousNo Effect
50 months Nurse visited during pregnancy and comparison (Elmira) 209 children Adjusted mean = 0.11 Adjusted mean = 0.11 Mean difference = 0.00 Not available Statistical significance not reported
Number of hospital admissions (25 to 50 months)
FavorableUnfavorable or ambiguousNo Effect
50 months Nurse visited during pregnancy + infancy and comparison (Elmira) 221 children Adjusted mean = 0.14 Adjusted mean = 0.11 Mean difference = 0.03 Not available Not statistically significant,
p > 0.05

footnote1

Submitted by user on

Statistical significance reported on authors’ calculations of the log-incidence difference.

Number of scheduled health supervision visits (25 to 50 months)
FavorableUnfavorable or ambiguousNo Effect
50 months Nurse visited during pregnancy and comparison (Elmira) 209 children Adjusted mean = 1.27 Adjusted mean = 1.56 Mean difference = -0.29 Not available Statistical significance not reported
Number of scheduled health supervision visits (25 to 50 months)
FavorableUnfavorable or ambiguousNo Effect
50 months Nurse visited during pregnancy + infancy and comparison (Elmira) 221 children Adjusted mean = 1.26 Adjusted mean = 1.56 Mean difference = -0.30 Not available Not statistically significant,
p > 0.05
Number of scheduled health supervision visits with problems (25 to 50 months)
FavorableUnfavorable or ambiguousNo Effect
50 months Nurse visited during pregnancy + infancy and comparison (Elmira) 221 children Adjusted mean = 6.24 Adjusted mean = 6.72 Mean difference = -0.48 Not available Not statistically significant,
p > 0.05
Number of scheduled health supervision visits with problems (25 to 50 months)
FavorableUnfavorable or ambiguousNo Effect
50 months Nurse visited during pregnancy and comparison (Elmira) 209 children Adjusted mean = 5.18 Adjusted mean = 6.72 Mean difference = -1.54 Not available Statistical significance not reported
NFP with Paraprofessional Home Visitors - Mothers with low psychological resources subgroup
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance Notes
Subsequent NICU/special care admission (rate per subsequent birth)
FavorableUnfavorable or ambiguousNo Effect
6-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 641 mothers % (adjusted) = 18.00 Adjusted mean % = 23.00 OR = -0.72 HomVEE calculated = -0.20 Not statistically significant,
p = 0.14

footnote2

Submitted by user on

Statistical significance reported on authors’ calculations of the odds ratio.

Subsequent low birth weight newborn (rate per subsequent birth)
FavorableUnfavorable or ambiguousNo Effect
6-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 641 mothers % (adjusted) = 11.00 Adjusted mean % = 16.00 OR = -0.69 HomVEE calculated = -0.22 Not statistically significant,
p = 0.16

footnote2

Submitted by user on

Statistical significance reported on authors’ calculations of the odds ratio.

NFP with Paraprofessional Home Visitors - Mothers with low psychological resources subgroup
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance Notes
Number of infant and childhood deaths among firstborn children (birth–9 years)
FavorableUnfavorable or ambiguousNo Effect
9-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 627 mothers per 1,000 = 4.50 per 1,000 per 1,000 = 20.08 per 1,000 OR = 0.22 Not available Not statistically significant,
p = 0.80

footnote2

Submitted by user on

Statistical significance reported on authors’ calculations of the odds ratio.

Number of subsequent low birth weight newborns (0–9 years postpartum)
FavorableUnfavorable or ambiguousNo Effect
9-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 627 mothers Adjusted mean = 0.18 Adjusted mean = 0.27 Mean difference = -0.09 Not available Not statistically significant,
p = 0.07

footnote4

Submitted by user on

Statistical significance reported on authors’ calculation of incidence ratio.

NFP with Paraprofessional Home Visitors - Mothers with low psychological resources subgroup
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance
Subsequent low birth weight newborns
FavorableUnfavorable or ambiguousNo Effect
4-year follow-up Nurse home visitor and comparison (Denver) 424 mothers = 0.06 = 0.08 OR = 0.75 HomVEE calculated = -0.17 Not statistically significant,
p = 0.45
Subsequent special care admissions
FavorableUnfavorable or ambiguousNo Effect
4-year follow-up Nurse home visitor and comparison (Denver) 424 mothers = 0.06 = 0.08 OR = 0.66 HomVEE calculated = -0.26 Not statistically significant,
p = 0.27

Findings rated moderate

NFP with Paraprofessional Home Visitors - Mothers with low psychological resources subgroup
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance Notes

Low birthweight of the second child

FavorableUnfavorable or ambiguousNo Effect

18 years

Nurse Family Partnership vs. comparison, Memphis New Mother's Study 1990-1991, mothers with second child

512 children Not reported Not reported Odds ratio = 0.51 Study reported = -0.41

Statistically significant, p <0.05

Preterm birth of the second child

FavorableUnfavorable or ambiguousNo Effect

18 years

Nurse Family Partnership vs. comparison, Memphis New Mother's Study 1990-1991, mothers with second child

470 children Not reported Not reported Odds ratio = 1.07 Study reported = 0.04

Not statistically significant, p ≥ 0.05

NFP with Paraprofessional Home Visitors - Mothers with low psychological resources subgroup
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance
Birth weight (grams)
FavorableUnfavorable or ambiguousNo Effect
Birth NFP-trained nurse visitors and comparison nurse visitors 156 children Mean = 3.00 Mean = 3.00 Mean difference = 164.26 HomVEE calculated = 0.29 Not reported
Gestational age (months)
FavorableUnfavorable or ambiguousNo Effect
Birth NFP-trained nurse visitors and comparison nurse visitors 154 children Mean = 38.88 Mean = 38.92 Mean difference = -0.04 HomVEE calculated = -0.02 Not reported
NFP with Paraprofessional Home Visitors - Mothers with low psychological resources subgroup
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance Notes
20 year child mortality rate - all causes (Nurse home visits during pregnancy and infancy vs. developmental screening comparison)
FavorableUnfavorable or ambiguousNo Effect
20 years Nurse home visits during pregnancy and infancy vs. developmental screening comparison (Memphis) 708 mother/child dyads Unadjusted mean = 0.01 Unadjusted mean = 0.03 Mean difference = -0.02 HomVEE calculated = -0.68 Not statistically significant, p = 0.11

footnote162

Submitted by user on

Negative value is favorable to the intervention.

20 year child mortality rate - preventable cause (Nurse home visits during pregnancy and infancy vs. developmental screening comparison)
FavorableUnfavorable or ambiguousNo Effect
20 years Nurse home visits during pregnancy and infancy vs. developmental screening comparison (Memphis) 708 mother/child dyads Unadjusted mean = 0.00 Unadjusted mean = 0.02 Mean difference = -0.02 Not available Statistically significant, p = 0.04

footnote162

Submitted by user on

Negative value is favorable to the intervention.

NFP with Paraprofessional Home Visitors
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance
Subsequent low birth weight newborns
FavorableUnfavorable or ambiguousNo Effect
4-year follow-up Paraprofessional. home visitor and comparison (Denver) 431 mothers = 0.03 = 0.08 OR = 0.34 HomVEE calculated = -0.64 Statistically significant,
p = 0.03
Subsequent special care admissions
FavorableUnfavorable or ambiguousNo Effect
4-year follow-up Paraprofessional home visitor and comparison (Denver) 431 mothers = 0.05 = 0.08 OR = 0.54 HomVEE calculated = -0.38 Not statistically significant,
p = 0.13
View Revisions